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J Gen Virol 73 (1992), 1537-1541; DOI 10.1099/0022-1317-73-6-1537
© 1992 Society for General Microbiology
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Analysis of human immunodeficiency virus type 1 LTR-LTR junctions in peripheral blood mononuclear cells of infected individuals

S. Jurriaans1, A. de Ronde2, J. Dekker1, J. Goudsmit1 and M. Cornelissen1

1 Human Retrovirus Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam
and2 Institute of Virology, University of Utrecht, Yalelaan 1, 3584 CL Utrecht, The Netherlands

Circularized DNA species containing two long terminal repeat circle junctions were analysed in peripheral blood mononuclear cells of human immunodeficiency virus type 1 (HIV-1)-infected individuals. The circle junction fragments found could be classified into four groups: fragments containing a normal circle junction, fragments with deletions at the circle junction, fragments containing the primer binding site inserted at the circle junction, and fragments containing insertions at the circle junction derived from other regions of the HIV-1 genome.

Received 14 October 1991; accepted 30 January 1992.


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