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J Gen Virol 73 (1992), 1559-1562; DOI 10.1099/0022-1317-73-6-1559
© 1992 Society for General Microbiology
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Non-permissiveness of synovial membrane cells to human parvovirus B19 in vitro

N. P. H. Miki{dagger} and J. K. Chantler

Division of Medical Microbiology, University of British Columbia, 2733 Heather Street, Vancouver, British Columbia V5Z 1M9, Canada

The ability of cultured human synovial cells derived from synovial membrane and cartilage to support the replication of human parvovirus B19 was assessed. No viral DNA synthesis nor viral antigens were detected suggesting that B19 virus is not capable of replicating in synovial cells. The significance of this finding in relationship to the pathogenesis of parvovirus arthritis is discussed.

{dagger} Present address: Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Received 20 January 1992; accepted 17 February 1992.


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