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J Gen Virol 73 (1992), 1645-1648; DOI 10.1099/0022-1317-73-7-1645
© 1992 Society for General Microbiology
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Variations in prion protein and glial fibrillary acidic protein mRNAs in the brain of scrapie-infected newborn mouse

Françoise Lazarini1, Jean-Philippe Deslys1 and Dominique Dormont1,2

1 Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, DSV/DPTE, Commissariat à l'Energie Atomique, B.P. 6, 92265 Fontenay aux Roses Cedex
and2 Institut Pasteur, Paris, France

To begin to understand the molecular basis of cases of Creutzfeldt-Jakob disease recently described in young children, the expression of prion protein and glial fibrillary acidic protein (GFAP) mRNAs was investigated during the development of the brain of scrapie-infected newborn mice. Changes in the time course of expression were identified by Northern blot quantification between days 1 and 172. Although scrapie-infected and control animals showed no detectable changes in brain development (first 56 days of life), GFAP mRNAs were found to increase significantly as early as day 84. A 10-fold increase in the level of GFAP mRNA was observed in brain between day 112 and death (day 172).

Received 30 December 1991; accepted 10 March 1992.


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