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The use of feline herpesvirus and baculovirus as vaccine vectors for the gag and env genes of feline leukaemia virus

Leonard E. Post

Animal Health Therapeutics Research, The Upjohn Company, 7000 Portage Road, Kalamazoo, Michigan 49001-0199, U.S.A.

The env and gag genes from feline leukaemia virus were expressed in a thymidine kinase-negative feline herpesvirus and a baculovirus. Cats were vaccinated with various combinations of these recombinant viruses and 100% protection against feline leukaemia virus challenge was achieved using an immunization schedule which utilized both env and gag products delivered at both a mucosal and systemic site.

Present address: Warner Lambert/Parke-Davis, 2800 Plymouth Road, Ann Arbor, Michigan 48106, U.S.A.

Received 3 January 1992; accepted 16 March 1992.

This article has been cited by other articles:

				L. Hanlon, D. Argyle, D. Bain, L. Nicolson, S. Dunham, M. C. Golder, M. McDonald, C. McGillivray, O. Jarrett, J. C. Neil, et al. Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 Expression Vectors J. Virol., September 15, 2001; 75(18): 8424 - 8433. [Abstract] [Full Text] [PDF]