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J Gen Virol 73 (1992), 2041-2045; DOI 10.1099/0022-1317-73-8-2041
© 1992 Society for General Microbiology

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The preS1 domain of hepatitis B virus and IgA cross-react in their binding to the hepatocyte surface

P. Pontisso1, M. G. Ruvoletto1, C. Tiribelli2, W. H. Gerlich3, A. Ruol1 and A. Alberti1

1 Istituto di Medicina Clinica, Clinica Medica 2, University of Padova,
2 Dipartimento di Biochimica e Biofisica, University of Trieste, Italy
and3 Institute for Medical Virology, Justus Liebig University, Giessen, Germany

Using a solid-phase assay we have demonstrated specific competition between the preS1 sequence of hepatitis B virus and human IgA in their binding to isolated normal human liver plasma membranes, suggesting molecular mimicry. Monoclonal and polyclonal antibodies raised against virus and IgA epitopes were used to detect and map immunological cross-reactivity to the virus sequence involved in liver cell binding. These findings suggest the existence of a common receptor or of closely related receptors for the attachment of HBV and IgA to human liver cells.

Received 7 February 1992; accepted 27 April 1992.


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