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J Gen Virol 73 (1992), 2445-2450; DOI 10.1099/0022-1317-73-9-2445
© 1992 Society for General Microbiology
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Highly conserved epitope domain in major core protein p24 is structurally similar among human, simian and feline immunodeficiency viruses

Kazuhiro Matsuo1, Yoshii Nishino2, Takuro Kimura2, Ryuji Yamaguchi1, Akihiro Yamazaki1, Takeshi Mikami3 and Kazuyoshi Ikuta2

1 Central Research Laboratories, Ajinomoto Co. Inc., Suzuki-cho 1-1, Kawasaki-ku, Kawasaki 210
2 Section of Serology, Institute of Immunological Science, Hokkaido University, Kita-ku, Sapporo 060
and3 Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan

Linear B cell epitopes were mapped on the major core protein p24 of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIVAGM) and feline immunodeficiency virus (FIV) using a fusion protein-based method and murine monoclonal antibodies reactive against the p24 antigens expressed on the surface of HIV-1- and FIV-infected cells. The results suggest that the sites identified here are encoded at similar positions in the three virus genomes and consist of highly conserved epitopes, which could exhibit immunodominance.

Received 27 March 1992; accepted 21 May 1992.


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Copyright © 1992 by the Society for General Microbiology.