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Molecular epidemiology of foot-and-mouth disease virus type O

¹ Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, 28049 Cantoblanco
and² Centro de Investigación en Sanidad Animal, INIA, 28130 Valdeolmos, Madrid, Spain

A phylogenetic tree based on the VP1 sequences of type O foot-and-mouth disease virus (FMDV) has been derived. Direct sequencing of PCR products has been used to obtain the VP1 gene sequences of new isolates. The tree exhibits four main lineages that largely correlate with the geographical origin of isolates. The analysis supports a close relationship between European O1 field isolates and vaccine strains, with the exception of O Thalheim Aus/81 and O Wuppertal Ger/82 which were probably of non-European origin. Analysis of nucleotide substitutions indicates that synonymous mutations play a major role in FMDV evolution.

Received 15 February 1993; accepted 11 June 1993.

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