| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institute of Biochemistry, Medical Faculty, University of Vienna, Dr Bohr Gasse 9/3, A-1030 Vienna, Austria
Amino acid sequence comparisons between the capsid proteins of several human rhinovirus (HRV) serotypes identified residues potentially involved in the discrimination between the major and the minor group receptors. Amino acids conserved within minor group HRVs were substituted in a full-length cDNA clone of HRV2 for those found at equivalent positions in major group HRVs. Transfection of HeLa cells with RNAs transcribed from seven individual mutated cDNAs gave rise to only two viable viruses; growth characteristics and affinity for the minor group receptor of both were unchanged compared to wild-type. Similar mutations in HRV14 were previously shown to alter the affinity for its receptor; the contact sites between the minor group viruses and the respective receptor may therefore be different.
Present address: Vienna International Research Cooperation Center, Brunner Strasse 59, A-1220 Vienna, Austria.
Present address: Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg, Austria.
Received 14 October 1992;
accepted 17 May 1993.
This article has been cited by other articles:
|
|
 |
|
  S. Kauder, S. Kan, and V. R. Racaniello Age-Dependent Poliovirus Replication in the Mouse Central Nervous System Is Determined by Internal Ribosome Entry Site-Mediated Translation J. Virol., March 15, 2006; 80(6): 2589 - 2595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vlasak, M. Roivainen, M. Reithmayer, I. Goesler, P. Laine, L. Snyers, T. Hovi, and D. Blaas The Minor Receptor Group of Human Rhinovirus (HRV) Includes HRV23 and HRV25, but the Presence of a Lysine in the VP1 HI Loop Is Not Sufficient for Receptor Binding J. Virol., June 15, 2005; 79(12): 7389 - 7395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vlasak, S. Blomqvist, T. Hovi, E. Hewat, and D. Blaas Sequence and Structure of Human Rhinoviruses Reveal the Basis of Receptor Discrimination J. Virol., June 15, 2003; 77(12): 6923 - 6930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Reithmayer, A. Reischl, L. Snyers, and D. Blaas Species-Specific Receptor Recognition by a Minor-Group Human Rhinovirus (HRV): HRV Serotype 1A Distinguishes between the Murine and the Human Low-Density Lipoprotein Receptor J. Virol., June 14, 2002; 76(14): 6957 - 6965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Reischl, M. Reithmayer, G. Winsauer, R. Moser, I. Gosler, and D. Blaas Viral Evolution toward Change in Receptor Usage: Adaptation of a Major Group Human Rhinovirus To Grow in ICAM-1-Negative Cells J. Virol., October 1, 2001; 75(19): 9312 - 9319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hertzler, M. Luo, and H. L. Lipton Mutation of Predicted Virion Pit Residues Alters Binding of Theiler's Murine Encephalomyelitis Virus to BHK-21 Cells J. Virol., February 15, 2000; 74(4): 1994 - 2004. [Abstract] [Full Text]
|
|
|
|
|
|
E. A. Hewat, T. C. Marlovits, and D. Blaas Structure of a Neutralizing Antibody Bound Monovalently to Human Rhinovirus 2 J. Virol., May 1, 1998; 72(5): 4396 - 4402. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
