J Gen Virol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 74 (1993), 2333-2338; DOI 10.1099/0022-1317-74-11-2333
© 1993 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stein, J.
Right arrow Articles by Prösch, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stein, J.
Right arrow Articles by Prösch, S.
Agricola
Right arrow Articles by Stein, J.
Right arrow Articles by Prösch, S.

Tumour necrosis factor {alpha} stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells

Joachim Stein1, Hans-Dieter Volk2, Christa Liebenthal2, Detlev H. Krüger1 and Susanna Prösch1

1 Institute of Virology
and2 Institute of Immunology, Humboldt University Medical School (Charité), Schumannstrasse 20/21, D-10098 Berlin, Germany

Both tumour necrosis factor {alpha} (TNF-{alpha}) and phorbol 12-myristate 13-acetate (PMA) stimulated human cytomegalovirus (HCMV) major immediate early (IE) enhancer/promoter activity in the HL-60 granulocyte/monocyte progenitor cell line when added to transfected cells. In U-937 monocytic cells, by contrast, TNF-{alpha} had no stimulatory effect and the addition of PMA produced only marginal stimulation. In the mature THP-1 monocytic cell line and in differentiated HL-60 cells, addition of TNF-{alpha} caused inhibition of the IE enhancer/promoter activity. The stimulating effect of PMA, as observed in the other cell lines, however, remained. Thus the effect of TNF-{alpha} on the major IE enhancer/promoter activity is determined by the degree of differentiation of the infected cells. Unlike TNF-{alpha} and PMA, the interleukins IL-1, IL-3, IL-6 as well as the cytokine GM-CSF were found to have no detectable influence on the activity of the IE enhancer/promoter activity which, likewise, was not affected by the presence of the modulator sequence. Since premonocytic cells are suggested to be sites of HCMV latency, the stimulation by TNF-{alpha} could be of potential pathophysiological significance.

Received 18 January 1993; accepted 7 July 1993.


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
T. Crough and R. Khanna
Immunobiology of Human Cytomegalovirus: from Bench to Bedside
Clin. Microbiol. Rev., January 1, 2009; 22(1): 76 - 98.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Chan, E. R. Bivins-Smith, M. S. Smith, P. M. Smith, and A. D. Yurochko
Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage
J. Immunol., July 1, 2008; 181(1): 698 - 711.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. H. Cook, J. Trgovcich, P. D. Zimmerman, Y. Zhang, and D. D. Sedmak
Lipopolysaccharide, Tumor Necrosis Factor Alpha, or Interleukin-1{beta} Triggers Reactivation of Latent Cytomegalovirus in Immunocompetent Mice
J. Virol., September 15, 2006; 80(18): 9151 - 9158.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. N. Kotton and J. A. Fishman
Viral Infection in the Renal Transplant Recipient
J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1758 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. S. Ostedgaard, T. Rokhlina, P. H. Karp, P. Lashmit, S. Afione, M. Schmidt, J. Zabner, M. F. Stinski, J. A. Chiorini, and M. J. Welsh
A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia
PNAS, February 22, 2005; 102(8): 2952 - 2957.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. O. Simon, C. K. Seckert, D. Dreis, M. J. Reddehase, and N. K. A. Grzimek
Role for Tumor Necrosis Factor Alpha in Murine Cytomegalovirus Transcriptional Reactivation in Latently Infected Lungs
J. Virol., January 1, 2005; 79(1): 326 - 340.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Gredmark, W. B. Britt, X. Xie, L. Lindbom, and C. Soderberg-Naucler
Human Cytomegalovirus Induces Inhibition of Macrophage Differentiation by Binding to Human Aminopeptidase N/CD13
J. Immunol., October 15, 2004; 173(8): 4897 - 4907.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Gredmark, T. Tilburgs, and C. Soderberg-Naucler
Human Cytomegalovirus Inhibits Cytokine-Induced Macrophage Differentiation
J. Virol., October 1, 2004; 78(19): 10378 - 10389.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Kercher and B. M. Mitchell
Persisting Murine Cytomegalovirus Can Reactivate and Has Unique Transcriptional Activity in Ocular Tissue
J. Virol., September 15, 2002; 76(18): 9165 - 9175.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Moutaftsi, A. M. Mehl, L. K. Borysiewicz, and Z. Tabi
Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells
Blood, April 15, 2002; 99(8): 2913 - 2921.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Soderberg-Naucler, D. N. Streblow, K. N. Fish, J. Allan-Yorke, P. P. Smith, and J. A. Nelson
Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent
J. Virol., August 15, 2001; 75(16): 7543 - 7554.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. Guetta, E. M Scarpati, and P. E DiCorleto
Effect of cytomegalovirus immediate early gene products on endothelial cell gene activity
Cardiovasc Res, June 1, 2001; 50(3): 538 - 546.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Hummel, Z. Zhang, S. Yan, I. DePlaen, P. Golia, T. Varghese, G. Thomas, and M. I. Abecassis
Allogeneic Transplantation Induces Expression of Cytomegalovirus Immediate-Early Genes In Vivo: a Model for Reactivation from Latency
J. Virol., May 15, 2001; 75(10): 4814 - 4822.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
G. Herbein and W. A. O'brien
Tumor Necrosis Factor (TNF)-{alpha} and TNF Receptors in Viral Pathogenesis
Exp Biol Med, March 1, 2000; 223(3): 241 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Guetta, V. Guetta, T. Shibutani, and S. E. Epstein
Monocytes Harboring Cytomegalovirus: Interactions With Endothelial Cells, Smooth Muscle Cells, and Oxidized Low-Density Lipoprotein : Possible Mechanisms for Activating Virus Delivered by Monocytes to Sites of Vascular Injury
Circ. Res., July 19, 1997; 81(1): 8 - 16.
[Abstract] [Full Text]

Home page
 BloodHome page
K. Staak, S. Prosch, J. Stein, C. Priemer, R. Ewert, W.-D. Docke, D. H. Kruger, H. D. Volk, and P. Reinke
Pentoxifylline Promotes Replication of Human Cytomegalovirus In Vivo and In Vitro
Blood, May 15, 1997; 89(10): 3682 - 3690.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Prosch, A.-K. Heine, H.-D. Volk, and D. H. Kruger
CCAAT/Enhancer-binding Proteins alpha and beta Negatively Influence the Capacity of Tumor Necrosis Factor alpha to Up-regulate the Human Cytomegalovirus IE1/2 Enhancer/Promoter by Nuclear Factor kappa B during Monocyte Differentiation
J. Biol. Chem., October 26, 2001; 276(44): 40712 - 40720.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1993 by the Society for General Microbiology.