| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Biochemistry, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920 Japan
2 Department of Pharmacology
and3 Third Department of Internal Medicine, School of Medicine
and4 Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920
and5 Research Laboratory Centre, Fukui Medical School, Fukui 910-11, Japan
The process of cell death caused by influenza virus infection in cultured MDCK and HeLa cells was analysed. This infection gave rise to nuclear fragmentation and chromatin condensation accompanied by chromosomal DNA fragmentation into oligonucleosomes. Chromosomal DNA fragmentation progressed concomitantly with cell lysis of MDCK cells and HeLa cells, producing high and low yields of virus particles, respectively, indicating that the extent of cell lysis was not proportional to the virus production. The endonuclease inhibitor zinc blocked DNA fragmentation in MDCK cells. Cycloheximide inhibited DNA fragmentation as well as cell lysis. Inhibition occurred when the drug was added to the medium within 2 h after infection but not efficiently at 4 h or later. Infection induced the Fas Ag gene, which encodes a possible apoptosis-mediating molecule, in the early infectious stage followed by the expression of Fas Ag on the cell surface. These results suggested that influenza virus infection causes apoptotic death of cultured cells, and their fate might be determined at an early stage of the infection by induction of an apoptotic gene.
Received 9 March 1993;
accepted 25 June 1993.
This article has been cited by other articles:
|
|
 |
|
  J. M. Ngunjiri, M. J. Sekellick, and P. I. Marcus Clonogenic Assay of Type A Influenza Viruses Reveals Noninfectious Cell-Killing (Apoptosis-Inducing) Particles J. Virol., March 15, 2008; 82(6): 2673 - 2680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Y. Lam, J. W. Tang, A. C. M. Yeung, L. C. M. Chiu, J. J. Y. Sung, and P. K. S. Chan Avian Influenza Virus A/HK/483/97(H5N1) NS1 Protein Induces Apoptosis in Human Airway Epithelial Cells J. Virol., March 15, 2008; 82(6): 2741 - 2751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Schaecher, E. Touchette, J. Schriewer, R. M. Buller, and A. Pekosz Severe Acute Respiratory Syndrome Coronavirus Gene 7 Products Contribute to Virus-Induced Apoptosis J. Virol., October 15, 2007; 81(20): 11054 - 11068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. P. Mok, D. C. W. Lee, C.-Y. Cheung, M. Peiris, and A. S. Y. Lau Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages J. Gen. Virol., April 1, 2007; 88(4): 1275 - 1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Cauthen, D. E. Swayne, M. J. Sekellick, P. I. Marcus, and D. L. Suarez Amelioration of Influenza Virus Pathogenesis in Chickens Attributed to the Enhanced Interferon-Inducing Capacity of a Virus with a Truncated NS1 Gene J. Virol., February 15, 2007; 81(4): 1838 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hashimoto, T. Moki, T. Takizawa, A. Shiratsuchi, and Y. Nakanishi Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice J. Immunol., February 15, 2007; 178(4): 2448 - 2457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bruns, N. Studtrucker, A. Sharma, T. Fossen, D. Mitzner, A. Eissmann, U. Tessmer, R. Roder, P. Henklein, V. Wray, et al. Structural Characterization and Oligomerization of PB1-F2, a Proapoptotic Influenza A Virus Protein J. Biol. Chem., January 5, 2007; 282(1): 353 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Turpin, K. Luke, J. Jones, T. Tumpey, K. Konan, and S. Schultz-Cherry Influenza Virus Infection Increases p53 Activity: Role of p53 in Cell Death and Viral Replication J. Virol., July 15, 2005; 79(14): 8802 - 8811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I. Marcus, J. M. Rojek, and M. J. Sekellick Interferon Induction and/or Production and Its Suppression by Influenza A Viruses J. Virol., March 1, 2005; 79(5): 2880 - 2890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Van Lenten, A. C. Wagner, M. Navab, G.M. Anantharamaiah, E. K.-W. Hui, D. P. Nayak, and A. M. Fogelman D-4F, an Apolipoprotein A-I Mimetic Peptide, Inhibits the Inflammatory Response Induced by Influenza A Infection of Human Type II Pneumocytes Circulation, November 16, 2004; 110(20): 3252 - 3258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takizawa, C. Tatematsu, K. Watanabe, K. Kato, and Y. Nakanishi Cleavage of Calnexin Caused by Apoptotic Stimuli: Implication for the Regulation of Apoptosis J. Biochem., September 1, 2004; 136(3): 399 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Liu, I. Mori, M. J. Hossain, L. Dong, K. Takeda, and Y. Kimura Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity J. Gen. Virol., February 1, 2004; 85(2): 423 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. A. Brydon, H. Smith, and C. Sweet Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release J. Gen. Virol., September 1, 2003; 84(9): 2389 - 2400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mozdzanowska, J. Feng, and W. Gerhard Virus-Neutralizing Activity Mediated by the Fab Fragment of a Hemagglutinin-Specific Antibody Is Sufficient for the Resolution of Influenza Virus Infection in SCID Mice J. Virol., August 1, 2003; 77(15): 8322 - 8328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Uchide and K. Ohyama Antiviral function of pyrrolidine dithiocarbamate against influenza virus: the inhibition of viral gene replication and transcription J. Antimicrob. Chemother., July 1, 2003; 52(1): 8 - 10. [Full Text] [PDF]
|
|
|
|
|
|
P. Clarke, S. M. Meintzer, L. A. Moffitt, and K. L. Tyler Two Distinct Phases of Virus-induced Nuclear Factor kappa B Regulation Enhance Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Virus-infected Cells J. Biol. Chem., May 9, 2003; 278(20): 18092 - 18100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Arndt, G. Wennemuth, P. Barth, M. Nain, Y. Al-Abed, A. Meinhardt, D. Gemsa, and M. Bacher Release of Macrophage Migration Inhibitory Factor and CXCL8/Interleukin-8 from Lung Epithelial Cells Rendered Necrotic by Influenza A Virus Infection J. Virol., August 12, 2002; 76(18): 9298 - 9306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Soguero, M. Joo, K. A. Chianese-Bullock, D. T. Nguyen, K. Tung, and Y. S. Hahn Hepatitis C Virus Core Protein Leads to Immune Suppression and Liver Damage in a Transgenic Murine Model J. Virol., August 12, 2002; 76(18): 9345 - 9354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Watanabe, A. Shiratsuchi, K. Shimizu, T. Takizawa, and Y. Nakanishi Role of Phosphatidylserine Exposure and Sugar Chain Desialylation at the Surface of Influenza Virus-infected Cells in Efficient Phagocytosis by Macrophages J. Biol. Chem., May 10, 2002; 277(20): 18222 - 18228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. P. Zhirnov, T. E. Konakova, T. Wolff, and H.-D. Klenk NS1 Protein of Influenza A Virus Down-Regulates Apoptosis J. Virol., February 15, 2002; 76(4): 1617 - 1625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Seo, O. Goloubeva, R. Webby, and R. G. Webster Characterization of a Porcine Lung Epithelial Cell Line Suitable for Influenza Virus Studies J. Virol., October 1, 2001; 75(19): 9517 - 9525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schultz-Cherry, N. Dybdahl-Sissoko, G. Neumann, Y. Kawaoka, and V. S. Hinshaw Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells J. Virol., September 1, 2001; 75(17): 7875 - 7881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Nichols, J. A. Niles, and N. J. Roberts Jr. Human Lymphocyte Apoptosis after Exposure to Influenza A Virus J. Virol., July 1, 2001; 75(13): 5921 - 5929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Lyles Cytopathogenesis and Inhibition of Host Gene Expression by RNA Viruses Microbiol. Mol. Biol. Rev., December 1, 2000; 64(4): 709 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shiratsuchi, M. Kaido, T. Takizawa, and Y. Nakanishi Phosphatidylserine-Mediated Phagocytosis of Influenza A Virus-Infected Cells by Mouse Peritoneal Macrophages J. Virol., October 1, 2000; 74(19): 9240 - 9244. [Abstract] [Full Text]
|
|
|
|
|
|
P. Clarke, S. M. Meintzer, S. Gibson, C. Widmann, T. P. Garrington, G. L. Johnson, and K. L. Tyler Reovirus-Induced Apoptosis Is Mediated by TRAIL J. Virol., September 1, 2000; 74(17): 8135 - 8139. [Abstract] [Full Text]
|
|
|
|
|
|
P. P. Chiou, C. H. Kim, P. Ormonde, and J.-A. C. Leong Infectious Hematopoietic Necrosis Virus Matrix Protein Inhibits Host-Directed Gene Expression and Induces Morphological Changes of Apoptosis in Cell Cultures J. Virol., August 15, 2000; 74(16): 7619 - 7627. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. Tumpey, X. Lu, T. Morken, S. R. Zaki, and J. M. Katz Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans J. Virol., July 1, 2000; 74(13): 6105 - 6116. [Abstract] [Full Text]
|
|
|
|
|
|
M. Gale Jr., S.-L. Tan, and M. G. Katze Translational Control of Viral Gene Expression in Eukaryotes Microbiol. Mol. Biol. Rev., June 1, 2000; 64(2): 239 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Behnia, K. A. Robertson, and W. J. Martin II Lung Infections : Role of Apoptosis in Host Defense and Pathogenesis of Disease Chest, June 1, 2000; 117(6): 1771 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fujimoto, J. Pan, T. Takizawa, and Y. Nakanishi Virus Clearance through Apoptosis-Dependent Phagocytosis of Influenza A Virus-Infected Cells by Macrophages J. Virol., April 1, 2000; 74(7): 3399 - 3403. [Abstract] [Full Text]
|
|
|
|
|
|
K. Mozdzanowska, K. Maiese, and W. Gerhard Th Cell-Deficient Mice Control Influenza Virus Infection More Effectively Than Th- and B Cell-Deficient Mice: Evidence for a Th-Independent Contribution by B Cells to Virus Clearance J. Immunol., March 1, 2000; 164(5): 2635 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. P. Zhirnov, T. E. Konakova, W. Garten, and H.-D. Klenk Caspase-Dependent N-Terminal Cleavage of Influenza Virus Nucleocapsid Protein in Infected Cells J. Virol., December 1, 1999; 73(12): 10158 - 10163. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. M. Tang, M. J. Korth, M. Gale Jr., M. Wambach, S. D. Der, S. K. Bandyopadhyay, B. R. G. Williams, and M. G. Katze Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58IPK Mol. Cell. Biol., July 1, 1999; 19(7): 4757 - 4765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Colamussi, M. R. White, E. Crouch, and K. L. Hartshorn Influenza A Virus Accelerates Neutrophil Apoptosis and Markedly Potentiates Apoptotic Effects of Bacteria Blood, April 1, 1999; 93(7): 2395 - 2403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rayet, J.-A. Lopez-Guerrero, J. Rommelaere, and C. Dinsart Induction of Programmed Cell Death by Parvovirus H-1 in U937 Cells: Connection with the Tumor Necrosis Factor Alpha Signalling Pathway J. Virol., November 1, 1998; 72(11): 8893 - 8903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Larochelle, L. Flamand, P. Gourde, D. Beauchamp, and J. Gosselin Epstein-Barr Virus Infects and Induces Apoptosis in Human Neutrophils Blood, July 1, 1998; 92(1): 291 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Antalis, M. La Linn, K. Donnan, L. Mateo, J. Gardner, J. L. Dickinson, K. Buttigieg, and A. Suhrbier The Serine Proteinase Inhibitor (Serpin) Plasminogen Activation Inhibitor Type 2 Protects against Viral Cytopathic Effects by Constitutive Interferon alpha /beta Priming J. Exp. Med., June 1, 1998; 187(11): 1799 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Takeuchi, H. Tsutsumi, M. Osaki, K. Haseyama, N. Mizue, and S. Chiba Respiratory Syncytial Virus Infection of Human Alveolar Epithelial Cells Enhances Interferon Regulatory Factor 1 and Interleukin-1beta -Converting Enzyme Gene Expression but Does Not Cause Apoptosis J. Virol., May 1, 1998; 72(5): 4498 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. King and S. Goodbourn STAT1 Is Inactivated by a Caspase J. Biol. Chem., April 10, 1998; 273(15): 8699 - 8704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Itoh, H. Hotta, and M. Homma Increased Induction of Apoptosis by a Sendai Virus Mutant Is Associated with Attenuation of Mouse Pathogenicity J. Virol., April 1, 1998; 72(4): 2927 - 2934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Nash, M. B. Purner, R. P. Leon, P. Clarke, R. C. Duke, and T. J. Curiel Toxoplasma gondii-Infected Cells Are Resistant to Multiple Inducers of Apoptosis J. Immunol., February 15, 1998; 160(4): 1824 - 1830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Selleri, T. Sato, L. Del Vecchio, L. Luciano, A. J. Barrett, B. Rotoli, N. S. Young, and J. P. Maciejewski Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-alpha in Chronic Myelogenous Leukemia Blood, February 1, 1997; 89(3): 957 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wada, M. Matsumura, Y. Ohba, N. Kobayashi, T. Takizawa, and Y. Nakanishi Transcription Stimulation of the Fas-encoding Gene by Nuclear Factor for Interleukin-6 Expression upon Influenza Virus Infection J. Biol. Chem., July 28, 1995; 270(30): 18007 - 18012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gjertsen, L. Cressey, S Ruchaud, G Houge, M Lanotte, and S. Doskeland Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line J. Cell Sci., January 12, 1994; 107(12): 3363 - 3377. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
