HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beauverger, P. Articles by Wild, T. F. Search for Related Content PubMed PubMed Citation Articles by Beauverger, P. Articles by Wild, T. F. Agricola Articles by Beauverger, P. Articles by Wild, T. F.

Measles virus antigens induce both type-specific and canine distemper virus cross-reactive cytotoxic T lymphocytes in mice: localization of a common L^d-restricted nucleoprotein epitope

Unité d'Immunologie et Stratégie Vaccinale, Institut Pasteur de Lyon, Avenue Tony-Gernier, 69365 Lyon, Cedex 07, France

We have studied the induction of the cytotoxic T lymphocyte (CTL) response to measles virus (MV) antigens expressed as vaccinia virus (VV) recombinants in a murine model. In C3H mice (H-2^k) only the nucleoprotein (NP) induced a CTL response and this was shown to be cross-reactive with the closely related canine distemper virus (CDV). The presentation of this antigen was shown to be K^k-restricted. In BALB/c mice (H-2^d), both the haemagglutinin (HA) and the NP induced a strong CTL response, the former being serotype-specific, whereas the latter cross-reacted with CDV. Both responses were found to be L^d-restricted. Based on the prediction for L^d T cell motifs, we tested a number of MV NP-derived nonapeptides for their capacity to sensitize P815 cells (H-2^d) for lysis by spleen cells from VV-NP-immunized mice. One of these peptides, comprising amino acids 281 to 289 (Tyr-Pro-Ala-Leu-Gly-Leu-His-Glu-Phe) was as effective as cells expressing the complete NP protein. This motif is conserved in the CDV NP.

Received 19 April 1993; accepted 7 July 1993.

This article has been cited by other articles:

				J. C. Marie, F. Saltel, J.-M. Escola, P. Jurdic, T. F. Wild, and B. Horvat Cell Surface Delivery of the Measles Virus Nucleoprotein: a Viral Strategy To Induce Immunosuppression J. Virol., November 1, 2004; 78(21): 11952 - 11961. [Abstract] [Full Text] [PDF]

				N. Etchart, P.-O. Desmoulins, K. Chemin, C. Maliszewski, B. Dubois, F. Wild, and D. Kaiserlian Dendritic Cells Recruitment and In Vivo Priming of CD8+ CTL Induced by a Single Topical or Transepithelial Immunization Via the Buccal Mucosa with Measles Virus Nucleoprotein J. Immunol., July 1, 2001; 167(1): 384 - 391. [Abstract] [Full Text] [PDF]

				C. Neumeister, R. Nanan, T. I. Cornu, C. G. K. Lüder, V. ter Meulen, H. Naim, and S. Niewiesk Measles virus and canine distemper virus target proteins into a TAP-independent MHC class I-restricted antigen-processing pathway J. Gen. Virol., February 1, 2001; 82(2): 441 - 447. [Abstract] [Full Text]

				J. Welter, J. Taylor, J. Tartaglia, E. Paoletti, and C. B. Stephensen Vaccination against Canine Distemper Virus Infection in Infant Ferrets with and without Maternal Antibody Protection, Using Recombinant Attenuated Poxvirus Vaccines J. Virol., July 15, 2000; 74(14): 6358 - 6367. [Abstract] [Full Text]

				A. I. Cardoso, N. Sixt, A. Vallier, J. Fayolle, R. Buckland, and T. F. Wild Measles Virus DNA Vaccination: Antibody Isotype Is Determined by the Method of Immunization and by the Nature of both the Antigen and the Coimmunized Antigen J. Virol., March 1, 1998; 72(3): 2516 - 2518. [Abstract] [Full Text] [PDF]