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Isolation and immunogenic properties of a monomeric form of the HA₁ subunit of the influenza virus haemagglutinin from infected cells

¹ Institut für Virologie, Frankfurter Straße 107
and² Biochemisches Institut, Friedrichstraße 24, Justus-Liebig-Universität, D-35392 Giessen, Germany

A monomeric, truncated form of the HA₁ subunit of the haemagglutinin of fowl plague virus can be isolated from chorioallantoic membranes of infected eggs. This type of soluble HA₁ seems to be generated by the elimination of the amino-terminal 19 amino acids from the native HA₁, including the disulphide linkage to the HA₂ subunit. The same type of truncated HA₁ could be isolated from a filtrate of the allantoic fluid of infected embryonated eggs. Antibodies prepared against this monomeric soluble form of HA₁ did not inhibit haemagglutination or neutralize viral infectivity, but interfered with virus release and would be expected to impair the spread of virus after infection.

Received 14 May 1993; accepted 30 July 1993.