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Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model

Cornelia S. McLean

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.

To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto syngeneic mice to form a differentiated epithelium, thus closely mimicking the natural infection. A delayed-type hypersensitivity response could be demonstrated after intradermal challenge with a vaccinia virus recombinant expressing the E7 protein. This response appeared to be specific for the E7 polypeptide and was mediated by CD4⁺ cells.

Present address: Cantab Pharmaceutical Research, 184 Science Park, Milton Road, Cambridge CB4 4GN, U.K.

Received 29 July 1992; accepted 5 October 1992.

This article has been cited by other articles:

				M. C. López and M. A. Stanley Cytokine profile of draining lymph node lymphocytes in mice grafted with syngeneic keratinocytes expressing human papillomavirus type 16 E7 protein J. Gen. Virol., May 1, 2000; 81(5): 1175 - 1182. [Abstract] [Full Text]