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Antagonistic modulation of human cytomegalovirus replication by transforming growth factor and basic fibroblastic growth factor

J. Alcami

C. V. Paya^>

Unité d'Immunologie Virale, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cédex 15, France

We studied the effect of two cytokines, basic fibroblastic growth factor (bFGF) and transforming growth factor beta (TGF-) on human cytomegalovirus (HCMV) replication in cultured human lung fibroblasts. We show that TGF- increases HCMV production, probably by a transcriptional mechanism, and that bFGF represses HCMV replication in a dose-dependent manner. These actions were antagonistic and the mechanisms involved were independent of the effects of these factors on cell DNA synthesis and proliferation.

Present address: Department of Microbiology, Centro de Investigacion, Hospital 12 de Octubre, 28041 Madrid, Spain.

^> Present address: Division of Infectious Diseases, Mayo Clinic, 200 1st Street S.W., Rochester, Minnesota 55905, U.S.A.

Received 21 May 1992; accepted 6 October 1992.

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