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The growth of cell culture-attenuated rinderpest virus in bovine lymphoblasts with B cell, CD4⁺ and CD8⁺ alpha/beta T cell and gamma/delta T cell phenotypes

K. A. J. Herniman^1,

W. I. Morrison^2,>

¹ Kenya Agricultural Research Institute, National Veterinary Research Centre, Muguga, PO Box 32, Kikuyu, Kenya
and² International Laboratory for Research on Animal Diseases, PO Box 30709, Nairobi, Kenya

Cloned bovine lymphoblastoid cell lines, transformed by the protozoan parasite Theileria parva were infected with cell culture-attenuated rinderpest virus vaccine. The virus grew readily in lymphoid B cells, CD4⁺ and CD8⁺ alpha/beta T cells and gamma/delta T cells producing new infectivity, viral antigens, c.p.e. and total cell death. There did not appear to be a predilection for any particular phenotype of lymphoblast. The results imply that if the vaccine causes immunosuppression, it could do so through a variety of mechanisms.

Mr. K. A. J. Herniman died shortly after the completion of this study.

^> Present address: Institute of Animal Health, Compton, Nr Newbury, Berks, RG16 0NN, U.K.

Received 1 July 1992; accepted 13 October 1992.

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