| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 MRC Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow, Glasgow G61 1QH
2 Centre for HIV Research, Division of Biological Sciences, University of Edinburgh, ICAPB-Crew Building, West Mains Road, Edinburgh EH9 3JN, U.K.
and3 Department of Biomedicine, University of Pisa, 56124 Pisa, Italy
The DNA sequences of structural genes of several U.K. and European isolates of feline immunodeficiency virus (FIV) were determined and compared with those of other worldwide isolates. Phylogenetic analyses of both gag and env sequences demonstrate that a Japanese isolate represents a distinct sequence subgroup, with corrected amino acid distances to the other isolates averaging 23% in env and 8% in gag. Analysis also reveals that an evolutionary radiation of FIV occurred with many isolates diverging at approximately the same time, and that although isolates from similar geographical sources often cluster together, there is evidence of more than one origin for FIV in the U.K., The Netherlands and Italy. Estimation of the numbers of silent and replacement nucleotide substitutions indicates the presence of constraints against amino acid changes in gag and conserved regions of env but suggests that positive selection for protein sequence changes operates in variable regions of env. The possible immunological forces underlying these changes are discussed.
Received 3 September 1992;
accepted 19 October 1992.
This article has been cited by other articles:
|
|
 |
|
  A. N. Martins, S. O. Medeiros, J. P. Simonetti, H. G. Schatzmayr, A. Tanuri, and R. M. Brindeiro Phylogenetic and Genetic Analysis of Feline Immunodeficiency Virus gag, pol, and env Genes from Domestic Cats Undergoing Nucleoside Reverse Transcriptase Inhibitor Treatment or Treatment-Naive Cats in Rio de Janeiro, Brazil J. Virol., August 15, 2008; 82(16): 7863 - 7874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Troyer, J. Pecon-Slattery, M. E. Roelke, W. Johnson, S. VandeWoude, N. Vazquez-Salat, M. Brown, L. Frank, R. Woodroffe, C. Winterbach, et al. Seroprevalence and Genomic Divergence of Circulating Strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae Species J. Virol., July 1, 2005; 79(13): 8282 - 8294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. de Rozieres, C. K. Mathiason, M. R. Rolston, U. Chatterji, E. A. Hoover, and J. H. Elder Characterization of a Highly Pathogenic Molecular Clone of Feline Immunodeficiency Virus Clade C J. Virol., September 1, 2004; 78(17): 8971 - 8982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Weaver, E. W. Collisson, M. Slater, and G. Zhu Phylogenetic Analyses of Texas Isolates Indicate an Evolving Subtype of the Clade B Feline Immunodeficiency Viruses J. Virol., February 15, 2004; 78(4): 2158 - 2163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Biek, A. G. Rodrigo, D. Holley, A. Drummond, C. R. Anderson Jr., H. A. Ross, and M. Poss Epidemiology, Genetic Diversity, and Evolution of Endemic Feline Immunodeficiency Virus in a Population of Wild Cougars J. Virol., September 1, 2003; 77(17): 9578 - 9589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Steinrigl and D. Klein Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics J. Gen. Virol., May 1, 2003; 84(5): 1301 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Giannecchini, A. Di Fenza, A. M. D'Ursi, D. Matteucci, P. Rovero, and M. Bendinelli Antiviral Activity and Conformational Features of an Octapeptide Derived from the Membrane-Proximal Ectodomain of the Feline Immunodeficiency Virus Transmembrane Glycoprotein J. Virol., March 15, 2003; 77(6): 3724 - 3733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Beatty, A. Terry, J. MacDonald, E. Gault, S. Cevario, S. J. O'Brien, E. Cameron, and J. C. Neil Feline Immunodeficiency Virus Integration in B-Cell Lymphoma Identifies a Candidate Tumor Suppressor Gene on Human Chromosome 15q15 Cancer Res., December 15, 2002; 62(24): 7175 - 7180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Beatty, J. J. Callanan, A. Terry, O. Jarrett, and J. C. Neil Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation? J. Virol., January 1, 1998; 72(1): 767 - 771. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
