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Increased transcription of interleukin-6 in the brains of mice with chronic enterovirus infection

¹ University of Glasgow, Department of Neurology, Southern General Hospital, Glasgow G51 4TF
and² University of Glasgow, Department of Pathology, Western Infirmary, Glasgow G12, U.K.

An animal model of chronic enteroviral infection was established by using PCR to detect viral genomes in animal tissues and to compare levels of transcription of a variety of cytokines in the brain. Chronic cocksackie-virus B1 infection was found in both brain and skeletal muscle of mice infected as neonates. The viral infection cleared by 240 days post-infection. Elevated levels of tumour necrosis factor and interleukin-6 (IL-6) would appear to be linked to acute and chronic infection respectively. Levels of IL-6 return to normal upon clearance of the virus.

Received 10 August 1992; accepted 26 November 1992.

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