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1 AFRC Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking GU24 0NF
and2 Division of Molecular Biology, AFRC Institute for Animal Health, Compton Laboratory, Compton, Newbury RG16 0NN, U.K.
We report the first complete nucleotide sequence of the picornavirus coxsackievirus B5 (CB5), strain 1954/UK/85, an isolate from a case of hand-foot-and-mouth disease. We have compared the sequence with those of other coxsackie B viruses, coxsackievirus A9, poliovirus and swine vesicular disease virus (SVDV). The genes encoding the three major capsid proteins are most closely related to those of SVDV but the 5' and 3' non-coding regions and the P3 gene are more similar to the corresponding regions in the other coxsackie B viruses than to those of SVDV. These observations are considered in the light of the antigenic and biochemical relationships between SVDV and CB5.
Received 8 September 1992;
accepted 24 December 1992.
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