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Nucleotide sequence comparison of the VP8* gene of rotaviruses possessing the AU-1 gene 4 allele

¹ Department of Microbiology
and² Department of Preventive Medicine, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
³ Virus Laboratory, Institute of Infectious Diseases, University of Pavia, Pavia, Italy
⁴ Department of Laboratory Medicine, Akita University School of Medicine, 1-1-1 Hondo Akita 010
and⁵ Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.

Of the five currently recognized alleles of the human rotavirus VP4 gene, the AU-1 allele has captured attention because of its possible non-human origin. The 5' 750 nucleotide region of the VP4 gene, encoding the VP8* fragment [amino acids (aa) 1 to 241] and the connecting peptide (aa 242 to 247), from 13 human and two feline rotavirus strains possessing the AU-1 allele was highly conserved both at the nucleotide sequence (93·8 to 99·7% identity) and amino acid level (95·5 to 100% identity) irrespective of the year and the place of isolation or of the host species from which these viruses were isolated. This is consistent with the hypothesis that the AU-1 allele of the VP4 gene has been maintained in both human and feline rotavirus gene pools.

Received 16 February 1992; accepted 2 April 1993.

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