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Sequence variability of the glycoprotein gene of bovine respiratory syncytial virus

VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, U.S.A.

Sequence variation in the attachment glycoprotein G of bovine respiratory syncytial virus (BRSV) was determined. The nucleotide sequences of the G mRNAs of the A51908 [GenBank] , VC464 and FS-1 strains of BRSV were compared with the published sequence of the BRSV strain 391-2. Nucleotide sequence alignment showed that overall they are highly conserved, with 90 to 97% identity. In addition, the coding region of strain A51908 [GenBank] was longer by 18 nucleotides at the 3' end. An 84 to 95% level of identity was observed among the deduced amino acid sequences of the G proteins of BRSV strains. A maximum divergence of 19% was found when the extracellular domains of the G proteins were compared. The level of diversity would be consistent, by analogy to the human respiratory syncytial viruses, with these BRSV strains forming a single subgroup.

Received 9 February 1993; accepted 30 April 1993.

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