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1 Department of Tumor Biology, Karolinska Institute, Box 60400, Stockholm, Sweden
2 Department of Virology, Cancer Institute, Hokkaido University School of Medicine, Sapporo 060
and3 Department of Otolaryngology, Sapporo Medical College, Sapporo 060, Japan
We analysed the terminal repeats of Epstein-Barr virus (EBV) in DNAs isolated from six lethal midline granuloma (LMG) biopsies. A single fused terminal fragment could be detected in each case, indicating that these angiocentric peripheral T cell lymphomas represent clonal proliferations of cells infected with EBV on a single occasion. Using reverse transcriptase-PCR, we detected EBV nuclear antigen (EBNA) 1 and latent membrane protein (LMP) 1, but not EBNA 2 messages in LMG biopsy RNAs. The splicing pattern of the EBNA 1 message was consistent with the usage of a promoter localized in the BamHI F fragment (F promoter). The BamHI W fragment repeats and LMP-coding sequences were highly methylated in all cases. In contrast, the LMP regulatory sequences were found to be hypomethylated or partially methylated, as in LMP-expressing nasopharyngeal carcinomas.
Present address: Microbiological Research Group of the National Institute of Hygiene, Budapest, Pihenö u. 1, H-1529 Hungary.
Received 15 January 1993;
accepted 11 August 1993.
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