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Epstein—Barr virus types 1 and 2 have nearly identical LMP-1 transforming genes

Jeffery Sample

Departments of Medicine, Microbiology and Molecular Genetics, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, U.S.A.

Although variation in the gene encoding the Epstein—Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93% identical to the prototype type 1 EBV strain B95-8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.

Present address: Department of Virology and Molecular Biology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105 and Department of Pathology, University of Tennessee Health Sciences Center, 800 Madison Avenue, Memphis, Tennessee 38163, U.S.A.

Received 3 February 1994; accepted 27 April 1994.

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