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Delineation of a Sequence Required for Nuclear Localization of the Protein Encoded by Varicella-zoster Virus Gene 61

MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.

All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the C₃HC₄ domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C₃HC₄ protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.

Received 6 June 1994; accepted 20 July 1994.

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