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Rotavirus Causes Selective Vimentin Reorganization in Monkey Kidney CV-1 Cells

¹ Department of Neuroscience, Karolinska Institute, Stockholm
and² Department of Virology, Swedish Institute for Infectious Disease Control, Karolinska Institute, S-105 21 Stockholm, Sweden

The effect of rotavirus infection on cytoskeletal organization was examined in cultured African green monkey kidney (CV-1) cells. Rhesus rotavirus caused significant and selective changes in the organization of the vimentin filament network without having any effect on microtubules or actin. Double-immunofluorescence studies showed that at 6 h post-infection, and in the absence of cytopathic effect, the normal arrays of vimentin fibres radiating from multiple sites around the nucleus were lost. Vimentin fibres became irregularly distributed in the cytoplasm and were totally disrupted in the later stages of infection. Vimentin reorganization occurred independent of extracellular Ca²⁺ levels.

Received 28 March 1994; accepted 31 May 1994.

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