| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Aviron, Burlingame, California 94010-2307
2 Biomedical Research Center, St Paul Children's Hospital, and Department of Pediatrics, University of Minnesota, U.S.A.
and3 Institute of Microbiology, Medical School, University of Bologna, Bologna, Italy
Introduction. Members of the Herpesviridae family are viruses with a core containing the viral DNA in the form of a torus, a capsid (100 nm in diameter and composed of 162 capsomers), a tegument, which is a structure of variable thickness between the capsid and the envelope, and an envelope. The envelope is the trilaminar outer covering which contains numerous protrusions of spikes consisting of virally encoded glycoproteins. The resulting diameter of the virion varies from 120 to 300 nm.
Herpesviruses have been divided into three subfamilies on the basis of biological properties. The Alphaherpesvirinae are herpesviruses with a variable host range, short replication cycle, rapid spread in cultured cells, a lytic effect on infected cells and a tropism for establishing a latent infection in sensory ganglia. The Betaherpesvirinae have a restricted host range, a longer replication cycle, an infection which progresses more slowly in cultured cells and a latent state that can be established in numerous cells and tissues.
This article has been cited by other articles:
|
|
 |
|
  S. M. Varnum, D. N. Streblow, M. E. Monroe, P. Smith, K. J. Auberry, L. Pasa-Tolic, D. Wang, D. G. Camp II, K. Rodland, S. Wiley, et al. Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome J. Virol., October 15, 2004; 78(20): 10960 - 10966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Kattenhorn, R. Mills, M. Wagner, A. Lomsadze, V. Makeev, M. Borodovsky, H. L. Ploegh, and B. M. Kessler Identification of Proteins Associated with Murine Cytomegalovirus Virions J. Virol., October 15, 2004; 78(20): 11187 - 11197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lantto, J. M. Fletcher, and M. Ohlin A divalent antibody format is required for neutralization of human cytomegalovirus via antigenic domain 2 on glycoprotein B J. Gen. Virol., August 1, 2002; 83(8): 2001 - 2005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hofmann, H. Sindre, and T. Stamminger Functional Interaction between the pp71 Protein of Human Cytomegalovirus and the PML-Interacting Protein Human Daxx J. Virol., May 3, 2002; 76(11): 5769 - 5783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu and B. J. Biegalke The Human Cytomegalovirus UL35 Gene Encodes Two Proteins with Different Functions J. Virol., March 1, 2002; 76(5): 2460 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Theiler and T. Compton Characterization of the Signal Peptide Processing and Membrane Association of Human Cytomegalovirus Glycoprotein O J. Biol. Chem., October 12, 2001; 276(42): 39226 - 39231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuzushima, N. Hayashi, H. Kimura, and T. Tsurumi Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8+ T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay Blood, September 15, 2001; 98(6): 1872 - 1881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lazzarotto, S. Varani, L. Gabrielli, S. Pignatelli, and M. P. Landini The tegument protein ppUL25 of human cytomegalovirus (CMV) is a major target antigen for the anti-CMV antibody response J. Gen. Virol., February 1, 2001; 82(2): 335 - 338. [Abstract] [Full Text]
|
|
|
|
|
|
E.-M. Borst, S. Mathys, M. Wagner, W. Muranyi, and M. Messerle Genetic Evidence of an Essential Role for Cytomegalovirus Small Capsid Protein in Viral Growth J. Virol., February 1, 2001; 75(3): 1450 - 1458. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. A. Bresnahan and T. E. Shenk UL82 virion protein activates expression of immediate early viral genes in human cytomegalovirus-infected cells PNAS, December 19, 2000; 97(26): 14506 - 14511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mirazimi, M. Mousavi-Jazi, V.-A. Sundqvist, and L. Svensson Free thiol groups are essential for infectivity of human cytomegalovirus J. Gen. Virol., November 1, 1999; 80(11): 2861 - 2865. [Abstract] [Full Text]
|
|
|
|
|
|
E. Beuken, G. Grauls, C. A. Bruggeman, and C. Vink The rat cytomegalovirus R32 gene encodes a virion-associated protein that elicits a strong humoral immune response in infected rats J. Gen. Virol., October 1, 1999; 80(10): 2719 - 2728. [Abstract] [Full Text]
|
|
|
|
|
|
N. Zini, M. C. Battista, S. Santi, M. Riccio, G. Bergamini, M. P. Landini, and N. M. Maraldi The Novel Structural Protein of Human Cytomegalovirus, pUL25, Is Localized in the Viral Tegument J. Virol., July 1, 1999; 73(7): 6073 - 6075. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. Battista, G. Bergamini, M. C. Boccuni, F. Campanini, A. Ripalti, and M. P. Landini Expression and Characterization of a Novel Structural Protein of Human Cytomegalovirus, pUL25 J. Virol., May 1, 1999; 73(5): 3800 - 3809. [Abstract] [Full Text]
|
|
|
|
|
|
A. Gallina, L. Simoncini, S. Garbelli, E. Percivalle, G. Pedrali-Noy, K. S. Lee, R. L. Erikson, B. Plachter, G. Gerna, and G. Milanesi Polo-Like Kinase 1 as a Target for Human Cytomegalovirus pp65 Lower Matrix Protein J. Virol., February 1, 1999; 73(2): 1468 - 1478. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. E. Greijer, J. M. G. van de Crommert, S. J. C. Stevens, and J. M. Middeldorp Molecular Fine-Specificity Analysis of Antibody Responses to Human Cytomegalovirus and Design of Novel Synthetic-Peptide-Based Serodiagnostic Assays J. Clin. Microbiol., January 1, 1999; 37(1): 179 - 188. [Abstract] [Full Text]
|
|
|
|
|
|
T. Lazzarotto, A. Ripalti, G. Bergamini, M. C. Battista, P. Spezzacatena, F. Campanini, P. Pradelli, S. Varani, L. Gabrielli, G. T. Maine, et al. Development of a New Cytomegalovirus (CMV) Immunoglobulin M (IgM) Immunoblot for Detection of CMV-Specific IgM J. Clin. Microbiol., November 1, 1998; 36(11): 3337 - 3341. [Abstract] [Full Text]
|
|
|
|
|
|
M. T. Huber and T. Compton The Human Cytomegalovirus UL74 Gene Encodes the Third Component of the Glycoprotein H-Glycoprotein L-Containing Envelope Complex J. Virol., October 1, 1998; 72(10): 8191 - 8197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Maidji, S. Tugizov, G. Abenes, T. Jones, and L. Pereira A Novel Human Cytomegalovirus Glycoprotein, gpUS9, Which Promotes Cell-to-Cell Spread in Polarized Epithelial Cells, Colocalizes with the Cytoskeletal Proteins E-Cadherin and F-Actin J. Virol., July 1, 1998; 72(7): 5717 - 5727. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
