| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Laboratoire de Virologie et Immunologie Moléculaires INRA, C.R.J., Domaine de Vilvert, 78350 Jouy-en-Josas, France
and2 Institut National de Recherches Veterinaires Groeselenberg, 99-B 1180 Brussels (Uccle), Belgium
It has been shown previously that the viral glycoprotein VP7 is a major target of cytotoxic T lymphocytes (CTLs) induced by bovine rotavirus RF in C57BL/6 mice. Here we show that these RF-specific CTLs recognize target cells infected with a recombinant vaccinia virus (rVV) expressing the SA11 (simian rotavirus) VP6 but not those infected with rVVs that express RF VP1, VP2 or VP3 core proteins. After immunization of mice with insect cells infected with recombinant baculoviruses that express the corresponding RF proteins a strong specific CTL response was generated against target cells infected with VP6 rVV and VP3 rVV, a weak one against the VP2 rVV but none against the VP1 rVV. Kb-restricted CTL epitopes were identified on VP6 and VP3 using allele-specific motifs. When peptides corresponding to these epitopes were used to restimulate in vitro the spleen cells from RF-immunized mice, CTLs specific for each peptide and its corresponding rVV were induced.
Received 18 August 1993;
accepted 11 October 1993.
This article has been cited by other articles:
|
|
 |
|
  J. Wei, J.-T. Li, X.-P. Zhang, Y. Tang, J.-X. Wang, B. Zhang, and Y.-Z. Wu Identification of an HLA-A*0201-restricted cytotoxic T-lymphocyte epitope in rotavirus VP6 protein. J. Gen. Virol., November 1, 2006; 87(Pt 11): 3393 - 3396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Agnello, C. A. Herve, A. Lavaux, M. Darniot, P. Guillon, A. Charpilienne, and P. Pothier Intrarectal Immunization with Rotavirus 2/6 Virus-Like Particles Induces an Antirotavirus Immune Response Localized in the Intestinal Mucosa and Protects against Rotavirus Infection in Mice. J. Virol., April 1, 2006; 80(8): 3823 - 3832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Jaimes, N. Feng, and H. B. Greenberg Characterization of Homologous and Heterologous Rotavirus-Specific T-Cell Responses in Infant and Adult Mice J. Virol., April 15, 2005; 79(8): 4568 - 4579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, L. A. Babiuk, and S. van Drunen Littel-van den Hurk Immunization with a bovine herpesvirus 1 glycoprotein B DNA vaccine induces cytotoxic T-lymphocyte responses in mice and cattle J. Gen. Virol., April 1, 2005; 86(4): 887 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Masopust, V. Vezys, E. J. Usherwood, L. S. Cauley, S. Olson, A. L. Marzo, R. L. Ward, D. L. Woodland, and L. Lefrancois Activated Primary and Memory CD8 T Cells Migrate to Nonlymphoid Tissues Regardless of Site of Activation or Tissue of Origin J. Immunol., April 15, 2004; 172(8): 4875 - 4882. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
