HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ladogana, A. Articles by Tsiang, H. Search for Related Content PubMed PubMed Citation Articles by Ladogana, A. Articles by Tsiang, H. Agricola Articles by Ladogana, A. Articles by Tsiang, H.

Modification of tritiated -amino-n-butyric acid transport in rabies virus-infected primary cortical cultures

¹ Rabies Unit, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
and² Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy

The role of brain neurotransmitter transport processes in rabies virus infection of neurons was examined. The uptake and release of -amino-n-butyric acid (GABA) in rabies virus-infected embryonic rat cortical neurons was assayed using tritiated ligands. A 45% reduction of [³H]GABA uptake was observed 3 days post-infection, when a maximum level of infectious particle release occurs. At this time, kinetic analysis revealed significant changes in V_max, whereas no changes were found in K_m values in comparison with the control values. K⁺ and veratridine-induced [³H]GABA release was increased in infected cultures (98% and 35%, respectively) as compared with control values. The results obtained from rabies virus-infected cultures provide some preliminary evidence of the involvement of GABA in the pathogenesis of rabies.

Received 14 July 1993; accepted 19 October 1993.

This article has been cited by other articles:

				X.-Q. Li, L. Sarmento, and Z. F. Fu Degeneration of Neuronal Processes after Infection with Pathogenic, but Not Attenuated, Rabies Viruses J. Virol., August 1, 2005; 79(15): 10063 - 10068. [Abstract] [Full Text] [PDF]

				Y. Jacob, H. Badrane, P.-E. Ceccaldi, and N. Tordo Cytoplasmic Dynein LC8 Interacts with Lyssavirus Phosphoprotein J. Virol., November 1, 2000; 74(21): 10217 - 10222. [Abstract] [Full Text]