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J Gen Virol 75 (1994), 895-900; DOI 10.1099/0022-1317-75-4-895
© 1994 Society for General Microbiology
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Expression of functional protease and subviral particles by vaccinia virus containing equine infectious anaemia virus gag and 5' pol genes

Travis C. McGuire1, Katherine I. O'Rourke2, Timothy V. Baszler1, Steven R. Leib1, Alberta L. Brassfield1 and William C. Davis1

1 Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University
and2 Animal Disease Research Unit, Agricultural Research Service, USDA, Pullman, Washington 99164-7040, U.S.A.

Cells infected with vaccinia viruses expressing the equine infectious anaemia virus (EIAV) gag gene (VGag) or gag plus the 5' pol encoding protease (VGag/PR) were evaluated with monoclonal antibody to a p26 capsid protein linear epitope (QEISKFLTD). Both recombinant viruses expressed Gag precursor protein (55K) whereas only VGag/PR expressed a detectable Gag-Pol fusion protein (82K) with a functional protease, shown by subviral particles containing processed p26. Horses inoculated with VGag/PR produced antibodies reactive with EIAV Gag proteins.

Received 20 July 1993; accepted 4 November 1993.


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