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1 United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, Washington 99164-7030
and2 Washington Animal Disease Diagnostic Laboratory, Washington State University, Pullman, Washington 99164-7034, U.S.A.
BALB/c and severe combined immunodeficiency (SCID) mice were inoculated intracerebrally or intraperitoneally with scrapie agent strain ME7 to examine the role of functional lymphocytes and follicular dendritic cells in splenic infectivity and PrPSc accumulation. Intracerebrally inoculated BALB/c and SCID mice developed the clinical signs and microscopic lesions characteristic of scrapie. Spleens from terminally affected BALB/c mice contained PrPSc which was detectable by immunoblot analysis; SCID mouse spleens did not contain detectable PrPSc. SCID mouse spleens collected during the first 90 days after intraperitoneal infection contained neither infectivity nor PrPSc.
Received 22 November 1993;
accepted 4 January 1994.
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