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J Gen Virol 75 (1994), 2069-2073; DOI 10.1099/0022-1317-75-8-2069
© 1994 Society for General Microbiology
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The fibre of bovine adenovirus type 3 is very long but bent

Rob W. H. Ruigrok1, Annie Barge1, Suresh K. Mittal2 and Bernard Jacrot3

1 EMBL Grenoble Outstation, c/o ILL, BP 156, 38042 Grenoble Cedex 9, France,
2 Veterinary Infectious Disease Organization, University of Saskatchewan, 124 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 0W0
and3 Institut de Biologie Structural, 41 Avenue des Martyrs, 38027 Grenoble Cedex 1, France

The sequence of the fibre of bovine adenovirus type 3 (BAd3) predicts an extremely long structure due to a large number of 15-residue repeats in the fibre shaft, the tail and head domains being similar in size to the human adenovirus fibres. The length of the fibre was confirmed using negative-strain electron microscopy of BAd3 pentons (fibre plus penton base). The fibre was found to be bent in several discrete places and the bending sites appear to correspond with irregular repeats in the shaft. We suggest that bending of the fibre is needed for the interaction of the penton base with the secondary receptors on the cell surface.

Received 21 December 1993; accepted 2 March 1994.


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