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Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus

R. J. Coelen^2,

¹ School of Veterinary Studies, Murdoch University, Murdoch WA 6150, Australia
² Department of Microbiology, University of Western Australia, Nedlands WA 6009, Australia
and³ Bali Cattle Disease Investigation Unit, PO Box 416, Denpasar, Bali, Indonesia

Jembrana disease virus, the cause of an acute, severe disease in Bali (Bos javanicus) cattle in Indonesia was recently identified as a retrovirus, and possibly a lentivirus. We have produced sequence data representing 598 bp of the pol gene, amplified by PCR from viral cDNA using broadly reactive universal primers for retroviruses and more specific genus-reactive primers for lentiviruses. When the sequence data were compared with that of known lentiviruses and other bovine retroviruses, the closest alignment was with bovine immunodeficiency-like lentivirus (BIV), showing 74% nucleotide sequence identity. This confirmed that JDV is a lentivirus and that it is distinguishable from BIV. The pathogenesis of Jembrana disease is most unusual for a lentivirus infection and differs markedly from that reported for BIV infection.

^* Author for correspondence. Fax +61 9 310 4144. e-mail wilcox@csuva x 1.murdoch.edu.au

Present address: Department of Biomedical and Tropical Veterinary Sciences, James Cook University of Northern Queensland, Townsville Q 4810, Australia.

Received 15 July 1994; accepted 30 September 1994.

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