HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, S.-L. Articles by Kuo, S.-W. Search for Related Content PubMed PubMed Citation Articles by Chen, S.-L. Articles by Kuo, S.-W. Agricola Articles by Chen, S.-L. Articles by Kuo, S.-W.

Differential induction and regulation of c-jun, junB, junD and c-fos by human papillomavirus type 11 E5a oncoprotein

Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China

The E5a gene of human papillomavirus type 11 (HPV-11) is a transforming oncogene. In this study, we investigated the mechanism of E5a induced transformation. Our results show that the expression of c-jun and junB, but not junD, was activated by HPV-11 E5a in NIH 3T3 cells and human epidermal keratinocytes. However, the expression of c-fos was activated by E5a in NIH 3T3 cells, but not in keratinocytes. We further investigated the mechanism of c-jun and junB induction by E5a. The amount of c-jun and junB RNAs correlated with the amount of E5a RNA in the heavy metal inducible system. E5a constitutively activated the expression of c-jun and junB at the initiation of transcription level. In addition, analyses of the effect of serum on c-jun expression in E5a transformed human epidermal keratinocytes show that EGF might have a stimulatory effect on c-jun gene expression in E5a expressing keratinocytes.

^* Author for correspondence. Fax +886 2 3686028. e-mail SLCHEN@NDMCI.NDMCTSGH.EDU.TW

Received 16 May 1995; accepted 3 July 1995.

This article has been cited by other articles:

				M. Nonnenmacher, J. Salmon, Y. Jacob, G. Orth, and F. Breitburd Cottontail rabbit papillomavirus e8 protein is essential for wart formation and provides new insights into viral pathogenesis. J. Virol., May 1, 2006; 80(10): 4890 - 4900. [Abstract] [Full Text] [PDF]

				J. Ghai, R. S. Ostrow, J. Tolar, R. C. McGlennen, T. D. Lemke, D. Tobolt, Z. Liu, and A. J. Faras The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3'-kinase in NIH 3T3 cells PNAS, November 12, 1996; 93(23): 12879 - 12884. [Abstract] [Full Text] [PDF]