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1 Department of Microbiology
2 Department of Pediatrics
and3 Department of Pathology, Fukui Medical School, Fukui 910-11, Japan
Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.
* Author for correspondence. Fax +81 776 61 8104.
Received 15 May 1995;
accepted 5 July 1995.
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