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J Gen Virol 76 (1995), 2881-2885; DOI 10.1099/0022-1317-76-11-2881
© 1995 Society for General Microbiology
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Pseudorabies virus early protein 0 transactivates the viral gene promoters

Shinji Watanabe1, Etsuro Ono1,2,*, Yukio Shimizu1,{dagger} and Hiroshi Kida1

1 Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine
and2 Laboratory of Animal Experiments, Institute of Immunological Science, Hokkaido University, Sapporo 060, Japan

Pseudorabies virus (PRV) early protein 0 (EP0) contains the RING finger domain with homology to the immediate-early (IE) protein ICP0 of herpes simplex virus type 1 (HSV-1). EP0 was detected by indirect immunofluorescence in the nuclei of the cells transfected with EP0 expression plasmid as is the case in cells infected with PRV. In transient expression assays, EP0 trans-activated the PRV IE, thymidine kinase (TK) and glycoprotein X (gX) promoters, indicating that EP0, like ICP0 of HSV-1, is a transactivating protein.

* Author for correspondence. Fax +81 11 757 0715. e-mail etsuro@imm.hokadai.ac.jp

{dagger} Present address: Division of Veterinary Microbiology, Kyoto Biken Laboratories, 24-16 Makishima-cho, Uji-city 611, Japan.

Received 3 April 1995; accepted 23 June 1995.


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