| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Medicine, Tenovus Building, University of Wales College of Medicine, Cardiff CF4 4XX, UK
and2 E. C. Slater Institute, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
PML is a protein associated with discrete spherical structures within the nucleus of normal cells. A defect in PML expression is observed in acute promyelocytic leukaemia as a consequence of a chromosomal translocation involving the genes encoding PML and the 
retinoic acid receptor (RAR). Disruption of PML bodies also occurs during herpes simplex virus infection after the immediate early protein Vmw110 has become associated with PML bodies. In this study, we followed the fate of PML bodies in human fibroblasts during the course of a human cytomegalovirus (CMV) infection. Disruption of PML bodies was observed to be dependent on de novo CMV gene expression and to occur within 4 h post-infection, concomitant with the onset of CMV IE gene expression. Although a transient increase in the number of PML bodies could be observed in some cells, PML exists predominantly as a diffuse nuclear protein during both the early and late stages of CMV infection. Although the function of PML bodies is still uncertain, their disruption may be important for efficient herpes virus replication.
* Author for correspondence. Fax +44 1222 745 003. e-mail WMDGWW@CARDIFF.AC.UK
Received 7 April 1995;
accepted 28 June 1995.
This article has been cited by other articles:
|
|
 |
|
  I. J. Groves and J. H. Sinclair Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression J. Gen. Virol., November 1, 2007; 88(11): 2935 - 2940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Woodhall, I. J. Groves, M. B. Reeves, G. Wilkinson, and J. H. Sinclair Human Daxx-mediated Repression of Human Cytomegalovirus Gene Expression Correlates with a Repressive Chromatin Structure around the Major Immediate Early Promoter J. Biol. Chem., December 8, 2006; 281(49): 37652 - 37660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Li, T. Macnaughton, L. Gao, and M. M. C. Lai RNA-Templated Replication of Hepatitis Delta Virus: Genomic and Antigenomic RNAs Associate with Different Nuclear Bodies. J. Virol., July 1, 2006; 80(13): 6478 - 6486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tamrakar, A. J. Kapasi, and D. H. Spector Human Cytomegalovirus Infection Induces Specific Hyperphosphorylation of the Carboxyl-Terminal Domain of the Large Subunit of RNA Polymerase II That Is Associated with Changes in the Abundance, Activity, and Localization of cdk9 and cdk7 J. Virol., December 15, 2005; 79(24): 15477 - 15493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. White and D. H. Spector Exon 3 of the Human Cytomegalovirus Major Immediate-Early Region Is Required for Efficient Viral Gene Expression and for Cellular Cyclin Modulation J. Virol., June 15, 2005; 79(12): 7438 - 7452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nevels, W. Brune, and T. Shenk SUMOylation of the Human Cytomegalovirus 72-Kilodalton IE1 Protein Facilitates Expression of the 86-Kilodalton IE2 Protein and Promotes Viral Replication J. Virol., July 15, 2004; 78(14): 7803 - 7812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Imai, N. Matsuda, K. Tanaka, A. Nakano, S. Matsumoto, and W. Kang Ubiquitin Ligase Activities of Bombyx mori Nucleopolyhedrovirus RING Finger Proteins J. Virol., December 20, 2002; 77(2): 923 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Marshall, K. V. Rowley, A. Rinaldi, I. P. Nicholson, A. M. Ishov, G. G. Maul, and C. M. Preston Activity and intracellular localization of the human cytomegalovirus protein pp71 J. Gen. Virol., June 1, 2002; 83(7): 1601 - 1612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gravel, J. Gosselin, and L. Flamand Human Herpesvirus 6 Immediate-Early 1 Protein Is a Sumoylated Nuclear Phosphoprotein Colocalizing with Promyelocytic Leukemia Protein-associated Nuclear Bodies J. Biol. Chem., May 24, 2002; 277(22): 19679 - 19687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. V. Bonilla, D. D. Pinschewer, P. Klenerman, V. Rousson, M. Gaboli, P. P. Pandolfi, R. M. Zinkernagel, M. S. Salvato, and H. Hengartner Effects of Promyelocytic Leukemia Protein on Virus-Host Balance J. Virol., March 19, 2002; 76(8): 3810 - 3818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang and Y. Xiong Control of p53 Ubiquitination and Nuclear Export by MDM2 and ARF Cell Growth Differ., April 1, 2001; 12(4): 175 - 186. [Abstract] [Full Text]
|
|
|
|
|
|
A. L. Adamson and S. Kenney Epstein-Barr Virus Immediate-Early Protein BZLF1 Is SUMO-1 Modified and Disrupts Promyelocytic Leukemia Bodies J. Virol., March 1, 2001; 75(5): 2388 - 2399. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Fabunmi, W. Wigley, P. Thomas, and G. DeMartino Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies J. Cell Sci., January 1, 2001; 114(1): 29 - 36. [Abstract] [PDF]
|
|
|
|
 |
|
 L. A. Hansen, C. C. Sigman, F. Andreola, S. A. Ross, G. J. Kelloff, and L. M. De Luca Retinoids in chemoprevention and differentiation therapy Carcinogenesis, July 1, 2000; 21(7): 1271 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. H. Kim, C. Y. Choi, and Y. Kim Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1 PNAS, October 26, 1999; 96(22): 12350 - 12355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Ishov, A. G. Sotnikov, D. Negorev, O. V. Vladimirova, N. Neff, T. Kamitani, E. T.H. Yeh, J. F. Strauss , III, and G. G. Maul PML Is Critical for ND10 Formation and Recruits the PML-interacting Protein Daxx to this Nuclear Structure When Modified by SUMO-1 J. Cell Biol., October 18, 1999; 147(2): 221 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. D. Goodrum and D. A. Ornelles Roles for the E4 orf6, orf3, and E1B 55-Kilodalton Proteins in Cell Cycle-Independent Adenovirus Replication J. Virol., September 1, 1999; 73(9): 7474 - 7488. [Abstract] [Full Text]
|
|
|
|
|
|
A. L. Adamson and S. Kenney The Epstein-Barr Virus BZLF1 Protein Interacts Physically and Functionally with the Histone Acetylase CREB-Binding Protein J. Virol., August 1, 1999; 73(8): 6551 - 6558. [Abstract] [Full Text]
|
|
|
|
|
|
S. Müller and A. Dejean Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption J. Virol., June 1, 1999; 73(6): 5137 - 5143. [Abstract] [Full Text]
|
|
|
|
|
|
C. S. Swindle, N. Zou, B. A. Van Tine, G. M. Shaw, J. A. Engler, and L. T. Chow Human Papillomavirus DNA Replication Compartments in a Transient DNA Replication System J. Virol., February 1, 1999; 73(2): 1001 - 1009. [Abstract] [Full Text]
|
|
|
|
|
|
J. Burkham, D. M. Coen, and S. K. Weller ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase J. Virol., December 1, 1998; 72(12): 10100 - 10107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Ahn, E. J. Brignole III, and G. S. Hayward Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PML Mol. Cell. Biol., August 1, 1998; 18(8): 4899 - 4913. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. I. Lamond and W. C. Earnshaw Structure and Function in the Nucleus Science, April 24, 1998; 280(5363): 547 - 553. [Abstract] [Full Text]
|
|
|
|
|
|
M. Alcalay, L. Tomassoni, E. Colombo, S. Stoldt, F. Grignani, M. Fagioli, L. Szekely, K. Helin, and P. G. Pelicci The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein Mol. Cell. Biol., February 1, 1998; 18(2): 1084 - 1093. [Abstract] [Full Text]
|
|
|
|
|
|
R. F. Greaves and E. S. Mocarski Defective Growth Correlates with Reduced Accumulation of a Viral DNA Replication Protein after Low-Multiplicity Infection by a Human Cytomegalovirus ie1 Mutant J. Virol., January 1, 1998; 72(1): 366 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. B. Borden, E. J. Campbell Dwyer, and M. S. Salvato An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm J. Virol., January 1, 1998; 72(1): 758 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gongora, G. David, L. Pintard, C. Tissot, T. D. Hua, A. Dejean, and N. Mechti Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein J. Biol. Chem., August 1, 1997; 272(31): 19457 - 19463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Ishov, R. M. Stenberg, and G. G. Maul Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment J. Cell Biol., July 14, 1997; 138(1): 5 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Grotzinger, K. Jensen, and H. Will The Interferon (IFN)-stimulated Gene Sp100 Promoter Contains an IFN-gamma Activation Site and an Imperfect IFN-stimulated Response Element Which Mediate Type I IFN Inducibility J. Biol. Chem., October 11, 1996; 271(41): 25253 - 25260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Strouboulis and A. Wolffe Functional compartmentalization of the nucleus J. Cell Sci., January 8, 1996; 109(8): 1991 - 2000. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
