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Protection of hamsters against experimental mumps virus (MuV) infection by antibodies raised against the MuV surface glycoproteins expressed from recombinant vaccinia virus vectors

¹ Service de Génétique Appliquée, University of Brussels, 24 rue de l'Industrie, B-1400 Nivelles, Belgium
and² Microbiology and Tumorbiology Center, Karolinska Institute, S-17177 Stockholm, Sweden

The fusion (F) and haemagglutinin—neuraminidase (HN) glycoproteins of mumps virus (MuV) have been produced in CV1 cells via vaccinia virus recombinants. Recombinant proteins accumulated in infected cells and were glycosylated. Upon reduction, the F protein product was completely converted into its subunits. Hamsters infected with vaccinia recombinants expressing either the F or HN proteins produced antibodies recognizing MuV antigens and neutralizing MuV infectivity in vitro. These antibodies provided protection against MuV-induced encephalitis in newborn hamsters.

^* Author for correspondence. Fax +32 67 287777. e-mail shouard@ulb.ac.be

Received 19 August 1994; accepted 25 October 1994.