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Interferon- strong cytopathic effect on human papillomavirus type 16-immortalized HPK-IA cell line, unexpectedly not shared by interferon-

Regina Elena Institute for Cancer Research - Laboratory of Virology, Via delle Messi d'Oro 156, 00158 Rome, Italy

We report a novel, unusually severe cytopathic effect of interferon- (IFN-). Data concerning antibody neutralization, induction and recovery time course, CPE₅₀ dose, impact on oxidative metabolic activity and 1D SDS-PAGE total cellular protein analysis are provided for preliminary characterization. This cytopathic effect appears to be linked to human papillomavirus type 16 (HPV-16) genome presence as it is markedly evident in the HPV-16-immortalized HPK-IA cell line, but is not induced in diploid keratinocytes. It is also not induced in highly malignant SiHa cells suggesting that it also requires a fairly conserved phenotype. This effect is unexpectedly not shared by IFN- pointing to a discrimination between IFN- and - signal despite the well-known sharing of a common receptor. It remains to be clarified whether this divergence, undetectable in other cellular systems, represents a direct effect of viral presence or a non-specific consequence of cellular homoeostatic disregulation induced by the papillomavirus genome.

^* Author for correspondence. Fax + 39 6 4180473.

Received 11 July 1994; accepted 14 October 1994.

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