J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 76 (1995), 1041-1045; DOI 10.1099/0022-1317-76-4-1041
© 1995 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carlier, D.
Right arrow Articles by Rossignol, J.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carlier, D.
Right arrow Articles by Rossignol, J.-M.
Agricola
Right arrow Articles by Carlier, D.
Right arrow Articles by Rossignol, J.-M.

Importance of the C terminus of the hepatitis B virus precore protein in secretion of HBe antigen

Damien Carlier1, Olivier Jean-Jean2, Nathalie Fouillot1, Hans Will3 and Jean-Michel Rossignol1,*

1 Laboratoire de Génétique des Virus, UPR 2431-CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette cedex
2 Département de Biologie, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris cedex 05, France
and3 Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Hamburg, Germany

The hepatitis B virus (HBV) e antigen (HBeAg) is a 15 kDa soluble antigen derived from a precursor protein (precore protein) by two processing events, cleavage of the N-terminal signal peptide and cleavage of the C-terminal 34 amino acids. So far, the role of the C-terminal sequences in secretion has not been analysed in full. In this study deletion of the last 60 amino acids was found to abrogate HBeAg secretion whereas deletions of the last 10, 25 or 39 amino acids decreased its secretion rate. These data demonstrate that C-terminal precore protein sequences are crucial for HBe secretion and determine its secretion rate.

* Author for correspondence. Fax +33 1 69 82 43 08. e-mail ROSSIGNOL_JM@CIT12.FR

Received 15 July 1994; accepted 5 December 1994.


This article has been cited by other articles:


Home page
 J. Virol.Home page
S. Laine, A. Thouard, J. Derancourt, M. Kress, D. Sitterlin, and J.-M. Rossignol
In Vitro and In Vivo Interactions between the Hepatitis B Virus Protein P22 and the Cellular Protein gC1qR
J. Virol., December 1, 2003; 77(23): 12875 - 12880.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Messageot, S. Salhi, P. Eon, and J.-M. Rossignol
Proteolytic Processing of the Hepatitis B Virus e Antigen Precursor. CLEAVAGE AT TWO FURIN CONSENSUS SEQUENCES
J. Biol. Chem., January 3, 2003; 278(2): 891 - 895.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Messageot, D. Carlier, and J.-M. Rossignol
The C Terminus of the Hepatitis B Virus e Antigen Precursor Is Required for a Tunicamycin-sensitive Step That Promotes Efficient Secretion of the Antigen
J. Biol. Chem., July 17, 1998; 273(29): 18594 - 18598.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1995 by the Society for General Microbiology.