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Nucleotide sequence of the herpes simplex virus type 2 gene encoding the protease and capsid protein ICP35

Pharmaceutical Products Division, Abbott Laboratories, D47D, AP9A, One Abbott Park Road, Abbott Park, IL 60064, USA

The complete nucleotide sequence of the gene encoding the protease and ICP35 capsid protein of herpes simplex virus (HSV) type 2 strain G has been determined. The gene consisits of a 1908 bp open reading frame capable of encoding 636 amino acids. Comparative nucleotide sequence analysis of the gene with published HSV-1 sequences revealed that the HSV-2 nucleic acid segment most likely encodes two distinct proteins. The first protein is the HSV-2 protease, which is required for the assembly of the herpes virus capsid. The second protein has been previously designated as ICP35 in HSV-1, and belongs to the family of herpesvirus capsid proteins.

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Received 19 October 1994; accepted 25 November 1994.

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