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CD4 down-modulation by ganglioside and phorbol ester inhibits human herpesvirus 7 infection

¹ First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791-02
and² Ehime College of Health Science, Tobe, Ehime 791-21, Japan

Recently, data demonstrating that CD4 is an essential component of the receptor for human herpesvirus 7 (HHV-7) as well as for human immunodeficiency virus have been accumulating. Since gangliosides and phorbol esters are known to induce selective down-modulation of cell surface CD4 expression, it might be expected that treatment with these agents would interfere with HHV-7 infection of CD4⁺ T cells. The present study, undertaken to verify this possibility, demonstrated that addition of monosialoganglioside-GM1 or 12-O-tetradecanoylphorbol 13-acetate effectively induced disappearance of CD4 from the cell surface and also reduced HHV-7 infectivity, as judged by the CPE on virus-infected cells and studies of indirect immunofluorescence, TCID₅₀ and semi-quantitative PCR of the HHV-7 genome. Taken together with previous studies, the present data strongly suggest that the CD4 molecule is a critical component of the receptor for HHV-7.

^* Author for correspondence. Fax +81 899 64 4766. e-mail yasukawa@m.ehime-u.ac.jp

Received 27 February 1995; accepted 15 May 1995.

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