| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
2 National Institute for Biological Standards and Control, South Mimms, Herts EN6 3QG, UK
The results of biochemical and immunoelectron microscopic studies provide evidence that the NB protein is an integral component of the influenza B virion. Its glycosylation and orientation in the membrane were shown to be equivalent to that of NB in the plasma membrane of virus-infected cells. Sensitivity to proteinase K showed that the N terminus is exterior to the virion and gold immunolabelling of freeze-fractured replicas showed that the C terminus is located in the interior of the virion. The similarities between NB of influenza B and M2 of influenza A viruses in structural features, their presence in the virion and possession of an ion channel activity suggest that, by analogy with the M2 protein, NB may also have a role in virus entry.
Present Address: Institute of Virology, Dubravska cesta 9, Bratislava 842 46, Slovakia.
Received 22 July 1996;
accepted 12 August 1996.
This article has been cited by other articles:
|
|
 |
|
  N. F. Crum-Cianflone Bacterial, Fungal, Parasitic, and Viral Myositis Clin. Microbiol. Rev., July 1, 2008; 21(3): 473 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hatta and Y. Kawaoka The NB Protein of Influenza B Virus Is Not Necessary for Virus Replication In Vitro J. Virol., May 15, 2003; 77(10): 6050 - 6054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Hoffmann, K. Mahmood, C.-F. Yang, R. G. Webster, H. B. Greenberg, and G. Kemble Rescue of influenza B virus from eight plasmids PNAS, August 20, 2002; 99(17): 11411 - 11416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Odagiri, J. Hong, and Y. Ohara The BM2 protein of influenza B virus is synthesized in the late phase of infection and incorporated into virions as a subviral component J. Gen. Virol., October 1, 1999; 80(10): 2573 - 2581. [Abstract] [Full Text]
|
|
|
|
|
|
K. V. Rowley, R. Harvey, and W. S. Barclay Isolation and characterization of a transfectant influenza B virus altered in RNA segment 6 J. Gen. Virol., September 1, 1999; 80(9): 2353 - 2359. [Abstract] [Full Text]
|
|
|
|
|
|
S. E. Lindstrom, Y. Hiromoto, H. Nishimura, T. Saito, R. Nerome, and K. Nerome Comparative Analysis of Evolutionary Mechanisms of the Hemagglutinin and Three Internal Protein Genes of Influenza B Virus: Multiple Cocirculating Lineages and Frequent Reassortment of the NP, M, and NS Genes J. Virol., May 1, 1999; 73(5): 4413 - 4426. [Abstract] [Full Text]
|
|
|
|
|
|
A. Pekosz and R. A. Lamb Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal sequence PNAS, October 27, 1998; 95(22): 13233 - 13238. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
