J Gen Virol Try Microbiology Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 77 (1996), 2781-2786; DOI 10.1099/0022-1317-77-11-2781
© 1996 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fawl, R. L.
Right arrow Articles by Fraser, N. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fawl, R. L.
Right arrow Articles by Fraser, N. W.
Agricola
Right arrow Articles by Fawl, R. L.
Right arrow Articles by Fraser, N. W.

Reactivation of herpes simplex virus from latently infected mice after administration of cadmium is mouse-strain-dependent

Randall L. Fawl1, Richard M. Gesser1,2,, Tibor Valyi-Nagi3 and Nigel W. Fraser1

The1 Wistar Institute, Room 317, 3601 Spruce Street, Philadelphia, PA 19104, USA
The2 Children's Hospital of Pennsylvania, Division of Allergy, Immunology, and Infectious Disease, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
3 Vanderbilt University Medical Center, Department of Pathology, 21st and Garland Avenues, Nashville, TN 37232, USA

It was previously reported that administration of cadmium (Cd) to CBA mice latently infected with herpes simplex virus (HSV) results in a high incidence of virus reactivation in vivo. In the present study, Cd-inducible reactivation was used to compare CBA with four other laboratory mouse strains. HSV reactivation, as measured by the recovery of infectious particles from latently infected trigeminal ganglia following Cd treatment, occurred predominantly in the CBA strain and was almost entirely absent from other strains tested. There was no correlation of strain-dependent Cd toxicity with the recovery of infectious virus. In situ examination of Cd-treated ganglia from latently infected CBA and BALB/c mice revealed that viral antigens were expressed exclusively in CBA specimens, but that viral replicative transcripts were expressed in both strains, although more strongly in CBA than in BALB/c specimens. We conclude that Cd treatment had induced reactivation of HSV from both mouse strains, and that the reactivation process was completed in CBA but not in BALB/c mice.

Received 4 March 1996; accepted 8 July 1996.


This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
T. Liu, K. M. Khanna, X. Chen, D. J. Fink, and R. L. Hendricks
CD8+ T Cells Can Block Herpes Simplex Virus Type 1 (HSV-1) Reactivation from Latency in Sensory Neurons
J. Exp. Med., April 24, 2000; 191(9): 1459 - 1466.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Tal-Singer, W. Podrzucki, T. M. Lasner, A. Skokotas, J. J. Leary, N. W. Fraser, and S. L. Berger
Use of Differential Display Reverse Transcription-PCR To Reveal Cellular Changes during Stimuli That Result in Herpes Simplex Virus Type 1 Reactivation from Latency: Upregulation of Immediate-Early Cellular Response Genes TIS7, Interferon, and Interferon Regulatory Factor-1
J. Virol., February 1, 1998; 72(2): 1252 - 1261.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1996 by the Society for General Microbiology.