| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
A new simian T-lymphotropic virus, STLV-PH969, was recently isolated from a wild-born Hamadryas baboon. Previous analysis had revealed that it differs sufficiently from the other HTLV/STLVs to be considered a new type, provisionally designated primate T-lymphotropic virus-L. Here we analyse a 3850 bp cDNA fragment spanning the 3' part of the STLV-PH969 genome. The fragment encodes three major proteins: Env, Tax and Rex. Sequence comparison and phylogenetic analysis indicate that in general STLV-PH969 tends to be more closely related to HTLV-II than to HTLV-I, although separate gene regions might have evolved under different constraints. Detailed comparison of the Env, Tax and Rex proteins among the HTLV-I, -II and STLV-PH969 prototypes reveals that the amino acid sequence of each protein shows a preferential conservation of functionally important domains. RNA-PCR on cytoplasmic messengers demonstrated splicing between a splice donor site immediately downstream of the env start codon, and two splice acceptor sites identified in the pX region. The predominant spliced messenger encodes both Tax and Rex. The other messenger potentially encodes a new viral protein from the proximal part of the pX region that is similar in amino acid composition to p12I and p10xI of HTLV-I and HTLV-II respectively. This genomic organization of the proximal pX region of STLV-PH969 is different from that found in HTLV-I and HTLV-II. Therefore, the distinct classification of this virus can be justified, not only in terms of sequence divergence but also in terms of its different genomic structure.
* Author for correspondence. Fax +32 16 332131. e-mail vanbruss@uz.kuleuven.ac.be
Received 26 June 1995;
accepted 12 October 1995.
This article has been cited by other articles:
|
|
 |
|
  S. A. Chevalier, N. L. Ko, S. Calattini, A. Mallet, M.-C. Prevost, K. Kehn, J. N. Brady, F. Kashanchi, A. Gessain, and R. Mahieux Construction and Characterization of a Human T-Cell Lymphotropic Virus Type 3 Infectious Molecular Clone J. Virol., July 1, 2008; 82(13): 6747 - 6752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Chevalier, M. Walic, S. Calattini, A. Mallet, M.-C. Prevost, A. Gessain, and R. Mahieux Construction and Characterization of a Full-Length Infectious Simian T-Cell Lymphotropic Virus Type 3 Molecular Clone J. Virol., June 15, 2007; 81(12): 6276 - 6285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Calattini, S. A. Chevalier, R. Duprez, P. Afonso, A. Froment, A. Gessain, and R. Mahieux Human T-Cell Lymphotropic Virus Type 3: Complete Nucleotide Sequence and Characterization of the Human Tax3 Protein J. Virol., October 1, 2006; 80(19): 9876 - 9888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Meertens and A. Gessain Divergent Simian T-Cell Lymphotropic Virus Type 3 (STLV-3) in Wild-Caught Papio hamadryas papio from Senegal: Widespread Distribution of STLV-3 in Africa J. Virol., December 6, 2002; 77(1): 782 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Meertens, R. Mahieux, P. Mauclere, J. Lewis, and A. Gessain Complete Sequence of a Novel Highly Divergent Simian T-Cell Lymphotropic Virus from Wild-Caught Red-Capped Mangabeys (Cercocebus torquatus) from Cameroon: a New Primate T-Lymphotropic Virus Type 3 Subtype J. Virol., January 1, 2002; 76(1): 259 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Slattery, G. Franchini, and A. Gessain Genomic Evolution, Patterns of Global Dissemination, and Interspecies Transmission of Human and Simian T-cell Leukemia/Lymphotropic Viruses Genome Res., June 1, 1999; 9(6): 525 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Vandamme, M. Salemi, M. Van Brussel, H.-F. Liu, K. Van Laethem, M. Van Ranst, L. Michels, J. Desmyter, and P. Goubau African Origin of Human T-Lymphotropic Virus Type 2 (HTLV-2) Supported by a Potential New HTLV-2d Subtype in Congolese Bambuti Efe Pygmies J. Virol., May 1, 1998; 72(5): 4327 - 4340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Letourneur, L d'Auriol, M. Dazza, M Peteers, I Bedjabaga, P Piot, E Delaporte, A Gessain, and N Monplaisir Complete nucleotide sequence of an African human T-lymphotropic virus type II subtype b isolate (HTLV-II-Gab): molecular and phylogenetic analysis J. Gen. Virol., February 1, 1998; 79(2): 269 - 277. [Abstract]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
