J Gen Virol Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 77 (1996), 511-518; DOI 10.1099/0022-1317-77-3-511
© 1996 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Foà-Tomasi, L.
Right arrow Articles by Campadelli-Fiume, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foà-Tomasi, L.
Right arrow Articles by Campadelli-Fiume, G.
Agricola
Right arrow Articles by Foà-Tomasi, L.
Right arrow Articles by Campadelli-Fiume, G.

Identification of an 85 kDa phosphoprotein as an immunodominant protein specific for human herpesvirus 7-infected cells

Laura Foà-Tomasi1,*, Maria Pia Fiorilli1, Elisa Avitabile1 and Gabriella Campadelli-Fiume1,2,

1 Department of Experimental Pathology, Section of Microbiology and Virology, University of Bologna, via San Giacomo 12, 40126 Bologna
and2 University of Milan, 3rd Faculty of Sciences, Via Ravasi 2, Varese, Italy

The reactivity of human cord blood sera was directed most frequently in Western blot assays to a protein with an apparent molecular mass of 85 kDa that belongs to the p85 complex, a family of antigenically related proteins identified previously in our laboratory with the aid of two MAbs. We show that the 85 kDa protein is phosphorylated. As antibodies present in the human sera were directed in part to proteins carrying cross-reactive epitopes between human herpesvirus 6 (HHV-6) and 7 (HHV-7), it is remarkable that reactivity to the 85 kDa phosphoprotein was maintained after preabsorption of the sera with HHV-6 antigen, but abolished after preabsorption with HHV-7 antigen. Therefore, the 85 kDa phosphoprotein may be considered a major determinant of the human immune response to HHV-7, discriminating HHV-6 from HHV-7 infection.

* Author for correspondence. Fax +39 51 251588. e-mail campadel@biocfarm.unibo.it

Received 13 September 1995; accepted 9 November 1995.


This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
M. Franti, J.-T. Aubin, G. De Saint-Maur, H. Kosuge, K. Yamanishi, A. Gautheret-Dejean, A. Garbarg-Chenon, J.-M. Huraux, and H. Agut
Immune Reactivity of Human Sera to the Glycoprotein B of Human Herpesvirus 7
J. Clin. Microbiol., January 1, 2002; 40(1): 44 - 51.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
A. Stefan, M. De Lillo, G. Frascaroli, P. Secchiero, F. Neipel, and G. Campadelli-Fiume
Development of Recombinant Diagnostic Reagents Based on pp85(U14) and p86(U11) Proteins To Detect the Human Immune Response to Human Herpesvirus 7 Infection
J. Clin. Microbiol., December 1, 1999; 37(12): 3980 - 3985.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Kempf, V. Adams, N. Wey, R. Moos, M. Schmid, E. Avitabile, and G. Campadelli-Fiume
CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B
PNAS, July 8, 1997; 94(14): 7600 - 7605.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1996 by the Society for General Microbiology.