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1 Department of Biomedical Science
and2 Department of Molecular Immunology, Faculty of Agriculture, University of Tokyo, 1-1-1 Yayoi, Bunkyo, 113 Tokyo, Japan
DBA/2 mice treated with anti-Mac1 monoclonal antibody (MAb) failed to develop encephalomyocarditis virus (EMCV)-induced diabetes and myocarditis. Virus concentrations and the number of viral RNA-positive cells in the pancreas and heart were significantly reduced in mice treated with anti-Mac1 MAb. Mac1-positive macrophages seem to be involved in EMCV-induced disease and to affect the replication of EMCV in target organs.
* Author for correspondence. Fax +81 3 5800 6926. e-mail aita@hongo.ecc.u-tokyo.ac.jp
Received 31 August 1995;
accepted 8 December 1995.
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