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J Gen Virol 77 (1996), 811-813; DOI 10.1099/0022-1317-77-4-811
© 1996 Society for General Microbiology
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Exposure to autoclaving or sodium hydroxide extends the dose-response curve of the 263K strain of scrapie agent in hamsters

D. M. Taylor* and K. Fernie

BBSRC & MRC Neuropathogenesis Unit, Institute for Animal Health, West Mains Road, Edinburgh EH9 3JF, UK

An analysis was made of incubation period data from experiments in which samples of brain-tissue infected with the 263K strain of scrapie agent were injected intracerebrally into hamsters following exposure of the tissue to autoclaving or sodium hydroxide. Where there was survival of infectivity, this often produced extended mean incubation periods compared with the maximal incubation periods in controls injected with untreated agent. These results confirmed that, after chemical or physical treatment, infectivity titre should not be calculated by comparing the incubation period from a single dilution-group against a standard dose-response curve for untreated agent.

* Author for correspondence. Fax +44 131 668 3872. e-mail David-M.Taylor@BBSRC.ac.uk

Received 15 September 1994; accepted 8 December 1995.


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