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J Gen Virol 77 (1996), 1169-1172; DOI 10.1099/0022-1317-77-6-1169
© 1996 Society for General Microbiology
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Transmission of donor Epstein—Barr virus (EBV) in transplanted organs causes lymphoproliferative disease in EBV-seronegative recipients

T. Haque1, J. A. Thomas1, K. I. Falk2, R. Parratt3, B. J. Hunt3, M. Yacoub3 and D. H. Crawford1,*

1 Viral Pathogenesis Unit, Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
2 Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden
and3 Research Haematology Unit and The Department of Cardiothoracic Surgery, Heart Science Centre, Harefield Hospital, Middlesex, UK

Epstein—Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD). To determine whether the donor EBV isolate is transmitted to the recipient via the allograft and causes PTLD, EBV isolates from four cases of PTLD in cadaveric heart and/or lung transplant recipients were compared with the donor isolates by PCR and DNA sequence analysis. Two recipients who were EBV seronegative at transplantation acquired an EBV isolate indistinguishable from that of the donor and developed PTLD. In contrast, in two patients who were seropositive before transplantation, the donor isolate differed from that present in PTLD of the recipient. The results suggest that the acquisition of donor EBV is a risk factor for PTLD development in a previously seronegative transplant recipient.

* Author for correspondence. Fax +44 171 637 4314. e-mail d.crawford@lshtm.ac.uk

Received 6 December 1995; accepted 29 January 1996.


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