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1 Hepatology Division, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi 329-04
2 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo, Tokyo
and3 Second Department of Internal Medicine, Faculty of Medicine, University of Showa, Hatanodai, Tokyo, Japan
Cytotoxic T lymphocytes (CTLs) may play a role in host defence against hepatitis C virus (HCV) infection, and HCV-specific CTL epitopes may be included in vaccines to induce protective CTLs. We identified three new epitopes within the HCV nucleoprotein recognized by CTLs. HCV nucleoprotein residues 28–37 are the minimal epitope recognized by CTLs in association with the class I human leukocyte antigen B60, and epitopes in HCV nucleoprotein residues 111–130 and 161–180 are both recognized by CTLs in association with the class II human leukocyte antigen DRB1*08032.
* Author for correspondence. Fax +81 285 40 6054. e-mail imawari@ari.bekkoame.or.jp
Received 24 October 1995;
accepted 23 January 1996.
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