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J Gen Virol 77 (1996), 1323-1327; DOI 10.1099/0022-1317-77-6-1323
© 1996 Society for General Microbiology
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The translation-enhancing region of the Semliki Forest virus subgenome is only functional in the virus-infected cell

E. Mathilda Sjöberg* and Henrik Garoff

Karolinska Institute, Department of Biosciences at Novum, S-141 57 Huddinge, Sweden

We have recently shown that the Semliki Forest virus (SFV) subgenome contains a translation enhancer region in the coding part of its RNA. The enhancer increases the translation of the viral structural genes approximately ten-fold and thereby plays a key role in virus assembly. In this study we conclusively show that this translation enhancer represents an adaptation to the

* Author for correspondence. Fax +46 8774 55 38. e-mail mathilda.sjoberg@cbt.ki.se

Received 31 August 1995; accepted 12 January 1996.


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