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J Gen Virol 77 (1996), 1739-1743; DOI 10.1099/0022-1317-77-8-1739
© 1996 Society for General Microbiology
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Semi-permissive replication and functional aspects of the immune response in a cotton rat model of human parainfluenza virus type 3 infection

Martin G. Ottolini1, David D. Porter2, Val G. Hemming1, Sally A. Hensen1, Iman R. Sami3 and Gregory A. Prince4

1 Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA
2 Department of Pathology and Laboratory Medicine, University of California School of Medicine, Los Angeles, CA 90024, USA
3 Department of Pulmonary Medicine, Children's National Medical Center, and Department of Pediatrics, the George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
4 Virion Systems, Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA

A cotton rat (Sigmodon fulviventer) model of human parainfluenza virus type 3 (HPIV-3) infection was used to study patterns of HPIV-3 replication in naive and immune hosts. Growth curves revealed that nasal and pulmonary tissues of naive animals were semi-permissive for virus replication, with amounts of progeny virus proportional to inoculating doses. In naive animals there was a total eclipse in nasal tissues beginning 4 h after inoculation. By contrast, there was only partial eclipse of virus in pulmonary tissues, most pronounced at 1 h after inoculation. Immune animals demonstrated a delayed eclipse in pulmonary tissues upon rechallenge. Infection with very low doses of HPIV-3 induced complete protection against high-dose challenge in the absence of systemic neutralizing antibody, suggesting a significant role for other systemic or local immune effectors.

Received 6 December 1995; accepted 2 April 1996.




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Copyright © 1996 by the Society for General Microbiology.